The Amoeba Boys are a gang of Amoeba. With their gangster affectations, these aspiring criminals would love nothing more than to be regarded as serious villains worthy of fighting, and even getting beaten up and sent to jail by the Powerpuff Girls. Unfortunately, their brains are far too primitive to devise a crime above the level of littering or jaywalking. They are definitely Townsville's least malicious villains, even having a friendship-of-sorts with The Powerpuff Girls. They are generally harmless, but their actions have on several occasions endangered both the girls and the town purely by accident.
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