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The Gangreen Gang are a gang of monstrous teenaged hoodlums that are green-skinned and disreputable and unhealthy looking (as if suffering from gangrene). They originally appeared alongside the The Amoeba Boys in McCracken's original short, Whoopass Stew, as the villains The Powerpuff Girls are shown fighting in the introduction (rather than fighting every single major recurring villain on the show). They are a tribute to the works of cartoonist Ed Roth, particularly Rat Fink. They also bear a slight resemblance to The Gorillaz and Fat Albert and the Cosby Kids.

Ace, Snake, Grubber and Little Arturo have black hair while Big Billy has red hair. At the end of the episode "Telephonies" they were beaten up by Mojo Jojo, HIM and Fuzzy Lumpkins for making crank calls to the girls which left Mojo, Fuzzy, and Him at the receiving end of their fists when they were simply reading, taking a bath and exercising, none of them intending to attack the city that day.

In the movie, the Gang are the secondary antagonists. First, they (actually, it was the leader, Ace) punch the Professor before he returns home from shopping. They are revealed to be the first villains Blossom, Bubbles, and Buttercup encountered. This was when they were trying to walk home due to being forbidden to use their powers. Suddenly, they are knocked out by none other than Jojo (The Professor's former lab assistant who later became known as Mojo Jojo). Finally, they are the first villains the girls fight since the latter group is hired as local superheroes, because the gang are eating from a lady's grocery bags. At last, after Blossom beats Ace, Bubbles beats Snake and Grubber, and Buttercup beats Big Billy and Little Arturo, and put them in jail with Mojo and Fuzzy Lumpkins. Copyright: http://powerpuff.wikia.com/wiki/Gangreen_Gang

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