HIM is a mysterious, super-powerful, red-skinned, transvestite devil creature. He has large lobster-like claws, pointed ears, black widow's peak hair, yellow-green eyes, a hooked nose and a long, curled beard. He has three long eyelashes on each eyelid, rosy red cheeks and black lipstick. A lady's red jacket and skirt with pink tulle at the collar and hemline, a black leather belt with a bronze buckle, and black, thigh-high, spike-heeled boots (hooker boots) complete his look. It is implied that he is the devil himself, or at least some form of demon, in The Powerpuff Girls series, he is said to be "so sinister, so evil, so scary, so horribly vile that his real name can never be said." Very little is known about Him's motives for wanting to harm the Powerpuff Girls. In his first appearance, he shows a strong contempt towards them, but the main focus of his monologue is pointed towards being humiliated by the recent defeat of one of his monsters, rather than an overall explanation. He often plays on weaknesses in the group like fears, and seems to have a goal of breaking up their group, mainly through making them hate or fight each other. A goal of killing or destroying them is implied, but never fully shown, as this would be inappropriate considering the target audience of the show. He talks in a chilling voice that echoes at all times, to varying degrees depending on situations. He has two distinct manners of speaking; one is a high-pitched falsetto, and the other is a growling, sinister basso profondo. They will switch back and forth, especially from soft and sweet when pleased to loud and aggressive when angered. While most villains prefer to destroy Townsville themselves or through their own sheer strength, HIM often orchestrates events and psychological tortures in an attempt to drive the Powerpuff Girls apart or make them scared; many of which often come close to succeeding. Often times he uses Bubble's innocence and gullibility to move the plans along. He has shown numerous satanic forms, most of which are revealed in apocalyptic or hellish situations or realms. These forms, in turn can often greatly enhance his power and cause him to grow to enormous size, when engaged in battle he is an entity to be reckoned with.

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