May Kanker is the youngest of the three Kanker Sisters. She is in love with Ed, and much like his friends he is afraid of her and the other Kankers. She has blonde hair and buck teeth, and is usually seen wearing a gray T-shirt and red shorts. When she sleeps at night, she wears a pale blue one-piece footed sleeper. Unlike the other characters, her nose is shaped like a pig's nose. In the episode "Dawn of the Eds," it is hinted that her hair might be a wig. This, however, was most likely a gag as other episodes prove that May's hair is well attached to her head.
She also doesn't know the number to dial for 9-1-1 to call the cops in the episode "Run for your Ed." She is the most naïve Kanker and is the most prone to clumsy accidents and/or scrapes like Ed.